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  • 12Feb

    Since Creatine Monohydrate hit the shelves over 15 years ago nothing has been as consistent as a sports supplement. That is until now! Beta Alanine is being labelled ‘The Next Creatine’ – in that it will stand the test of time! Well over the past few years it has been proving itself with scientists and athletes. The research that has been done on Beta Alanine is incredible to say the least. But before we go diving head long into all the good stuff, here are some basics first. However if you already know the basics then jump straight to the amazing evidence.

     

    Beta Alanine: The Basics

    Unlike most amino acids, Beta Alanine is made in the body by the enzyme beta-ureidopropionase via Beta Alanine Synthase from eating protein rich foods. The most effective way to obtain it from natural dietary sources is through eating meat and fish. However to get enough Beta Alanine you would need to eat 1.5-2kg of chicken per day.[1]

     

    Therefore supplementing with Beta Alanine is required to get enough to have a substantial effect upon the body.

     

    How Does Beta Alanine Work?

    Most of the evidence of the effectiveness of Beta-Alanine is quite recent, and the mechanism by which it helps athletes is supposed to work by converting Beta Alanine into the amino acid carnosine in the muscles. Muscles with higher carnosine levels can contract harder for longer and produce greater force, leading to better muscular endurance and performance.[2]

     

    Carnosine works as buffering agent, reducing the amount of chemical by-products during intense exercise, such as lactic acid in your muscles.[3]  Not to be confused with bicarbonate of soda which buffers lactic acid in the bloodstream, Beta Alanine serves as an intramuscular buffer, allowing you to do more.[4]  Studies have shown Beta Alanine supplementation can increase intramuscular carnosine levels by up to 64%.[5],[6]

     

    • What does that mean? You exercise with less fatigue.
    • How?  It buffers the acidity in the muscle.


    Very Different to Creatine
    So if it’s the next creatine, does that mean that’s the end for creatine? No! Beta Alanine and creatine work very differently. Creatine provides a source of energy to muscle. Beta Alanine is a precursor of another compound – carnosine found in muscle – that buffers acidity and prolongs training.[7] However they can work synergistically and evidence points us to believe that creatine works better for the 1-6 rep range whilst Beta Alanine works better in the 7-12 rep range.
     

    The Evidence

    Most of the research available agrees that muscle carnosine synthesis is limited by the availability of Beta-Alanine.[8],[9] Therefore fatigue kicks in when carnosine levels are low. 

    Researchers in 2008 observed Beta Alanine supplementation in 8 male experienced weight trainees taking 4.8 gm per day for 30 days on resistance exercise performance.[10]  Their resistance exercise protocol consisted of 6 sets of 12 repetitions of the squat exercise at 70% of their one-repetition maximum (1-RM) with 1.5 minutes of rest between each set. After 4 weeks, the Beta-Alanine group was able to perform 22% more total repetitions.[11]

    There is also evidence that Beta Alanine effects slow twitch muscle fibres as well as fast twitch fibres and therefore helps endurance athletes. Two recent studies found that cyclists who supplemented with Beta-Alanine were able to get 13% more total work done after 4 weeks, and 16% more after 10 weeks compared to a group who didn’t use Beta-Alanine.[12],[13]

     

    Dr. Roger Harris, professor at the University of Chichester in the UK who was the earliest researcher of creatine monohydrate and the main proponent of its use in athletes, has been studying and working with Beta Alanine very closely. In 2005-2006 he had the South Korean Speed Skating team use Beta Alanine six months prior to the Winter Olympics and watched them claim a record 6 gold medals, 3 silver and 3 bronze in comparison to 2002 where they achieved 2 gold and 2 silver. [14],[15]

     

    Most individuals (male and female) will notice benefits within one week, but research has shown that the maximum benefit is observed after 10 weeks of use, so it is worth persisting with it for at least three months.[16]

     

     

    I personally noticed the benefits of taking Beta Alanine and within five weeks saw noticeable strength increase; of which I have put an example of in the video below. 

     
     
     

     

    Carnosine

    One question that many people ask is whether they shouldn’t simply skip the Beta-Alanine and supplement directly with carnosine – after all, Beta-Alanine seems to work by increasing carnosine levels.

     

    The answer lies in the nature of carnosine itself – unfortunately, when you ingest carnosine itself, most of it is broken down in the gastrointestinal (GI) tract.  The little that does escape into the blood suffers the same fate there. Thus it is actually far more effective to take Beta-Alanine.

     

    Beta Alanine & Creatine

    While many so called “performance stacks” are based on little more than wishful thinking, there is one that is based on solid and significant research – Beta-Alanine and Creatine combined.[17]

     

    Researchers have shown that combined Beta Alanine and Creatine Monohydrate supplementation produces a synergistic effect whereby total power output, fat-free mass gain, strength increases, and body fat reductions are all significantly greater than with creatine monohydrate supplementation alone.[18],[19]  Dr. Hoffman assembled a group of 33 college football players who had a minimum of 5 years weight training experience. In trials over 10 weeks comparing creatine alone and creatine plus Beta Alanine, the creatine plus Beta Alanine group gained 1 pound a week more muscle and lost fat, whilst not following any kind of diet.  Beta Alanine helps to lose fat. Wow!! Creatine by the way has never been shown to lose fat.

     

    Who is Beta Alanine For?

    Like creatine it works for just about everybody, and similarly you see and feel the effects. So you know its working.  However Beta Alanine is really for two main types of people:

     

     

     

    1 Anybody who wants to train beyond their current threshold. Beta Alanine will push you past any barriers or plateaus you have.

     

    2 Anybody who wants to look good. As you can do more work on Beta Alanine, a higher intensity with less fatigue is achieved therefore more muscle is built and in turn more fat calories are burned.

     

    Although its use as a supplement is still new, studies of up to 12 weeks have shown no negative changes across a wide range of blood, biochemical, haematological and hormonal markers making it safe to consume for up to 3 months.

     

    Dosage

    The research that has been conducted has used dosages of between 3.2 grams and 6.4 grams per day. Thus most conservative dosages suggest between 4-5 grams a day, typically taken 30 – 60 minutes before a workout and after a workout. However because of how Beta Alanine works, the goal is to get Beta Alanine saturated within the muscle cells, therefore most research has shown its better to take it in multiple smaller doses throughout the day. So 4-6 x 1g doses would work better. After 4 weeks you can then reduce the daily amount by half – so about 3g per day to keep carnosine levels high.[20] However it is always a good idea to take Beta Alanine with foods, to slow down its release into the body and prevent the body from wasting what it doesn’t need. Anymore than 6g is a dosage that is too excessive and is cautioned against states Dr Roger Harris.[21]

     

    When first used, some people experience a tingling and slight skin flushing similar to that of niacin.  This is completely harmless and will soon stop, but this is a sign that the dose was too high.


    Conclusion

    With such authoritive figures as, Dr Harris and renowned research scientist Dr. Jeff Stout publishing research on Beta Alanine and promoting its use as a performance enhancing sports supplement, the research and athletic communities are listening very hard, due to the impressive scientific data which supports its use. 

     

    Personal Recommendation

    Just buy a Pure Beta-Alanine powder, then work hard and feel it work. It is very inexpensive compared with many supplements that do not have a solid and growing body of research behind it and probably never will. Beta Alanine is one my favourites supplements for living strong, when you try it, I know it will become one of yours…Enjoy! 

    Copyright © by Professional Whey  


    [1] Jeff Stout. Performance Nutrition Show, Radio Interview, http://performancenutritionshow.com/pastshows/06_0628.html, June 28th, 2006.

     

    [2] Mike Greenwood, Douglas Kalman, Jose Antonio. Nutritional Supplements in Sports and Exercise, 2008.

     

    [3] Susan M. Kleiner, Maggie Greenwood-Robinson. Power Eating: Build Muscle, Increase Energy, Cut Fat, 2007. 

     

    [4] Jeff Stout. Performance Nutrition Show, Radio Interview, http://performancenutritionshow.com/pastshows/06_0628.html, June 28th, 2006.

     

    [5] Dunnett M & Harris RC. Influence of oral beta-alanine and L-Histidine supplementation on the carnosine content of gluteus medius. Equine Vet J 30: 499 – 504, 1999.

     
    [6] Harris RC, Tallon MJ, Dunnett M, Hill C, Boobis L, Coakley J, Fallowfield J, Kim HJ, Wise JA. The absorption of β-Alanine into blood and its effect on muscle carnosine synthesis in human vastus lateralis. In Press. Amino Acids, 2006.

     

    [7] Jeff Stout. Performance Nutrition Show, Radio Interview, http://performancenutritionshow.com/pastshows/06_0628.html, June 28th, 2006.

     

    [8] Derave, W, et al. Beta-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters, J Appl Physiology, 2007.

     

    [9] Kendrick IP, et al. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids, 34(4):547-54, 2008 May, Epub, Jan 4 2008.

     

    [10] Hoffman J, et al. Beta-Alanine and the Hormonal Response to Exercise, Int J Sports Med, 29(12): 952-8, Dec 1, 2008.

     

    [11] Hoffman J, et al. Beta-Alanine and the Hormonal Response to Exercise, Int J Sports Med, 29(12): 952-8, Dec 1, 2008.

     

    [12] Stout JR, et al.  Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women, Amino Acids, 2007;32(3):381-6. Epub, Nov 2006.

     

    [13] Hill, CA et al. Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity, Amino Acids, Volume 32, Number 2 / Feb 2007

     

    [14] Jeff Stout. Performance Nutrition Show, Radio Interview, http://performancenutritionshow.com/pastshows/06_0628.html, June 28th, 2006.

     

    [15] Wikipedia, South Korean Speed Skating 2006 Olympics Medals Table, http://en.wikipedia.org/wiki/South_Korea_at_the_2006_Winter_Olympics

     

    [16] Hill, Harris, Kim, Harris, Sale, Boobis, Kim, Wise. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity, Amino Acids, July 28 2006.

     

    [17] Zoeller RF, Stout JR, O’kroy JA, Torok DJ, Mielke M. Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion, Amino Acids, Sep 5 2006

     

    [18] Harris RC, Hill C, Wise JA. Effect of Combined ß-alanine and creatine monohydrate supplementation on exercise performance. Medicine & Science in Sports & Exercise. 35 Supplement 1:S218, May 2003. 

     

     

    [19] Hoffman J, Stout JR, et al.  Effect of creatine and ß-Alanine supplementation on performance and endocrine responses in strength/power athletes, In Press. International Journal of Sports Nutrition and Exercise Metabolism, 2006. 

    [20] Jeff Stout. Performance Nutrition Show, Radio Interview, http://performancenutritionshow.com/pastshows/06_0628.html, June 28th 2006.

     

    [21] Roger Harris, International Society of Sports Nutrition Conference, 2008.

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10 Responses

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  • Borhan Borhani Says:

    Hi – I love your blog. Great information, to the point and well supported. I’m now trying to put all of this info together to get ’stack’ that works for me…using your products. While you’ve supported stacking Beta alanine with Creatine, and Creatine with a high GI Carb – would you recommend putting all three together? Also, where would you place L-Glutamine in the scheme of thing? Your advice would be greatly appreciated…and will assist in my shopping (I want to purchase everything I need at once to save on shipping).

    BTW: the carb I had in mind for the stack was maltodextrin. Any blog posting comparing maltodexrin and dextrose would be greatly appreciated.

    Thanks for all the work on this blog.

  • Stephen Morris Says:

    Hi Borhan
    Thanks for your comments.
    Yes you can stack all three together and maltodextrin or dextrose is great to add for post workout uptake of nutrients. With glutamine it can also be used with them all as it supports the body in a completely different way. In fact Ive just been taking creatine, beta alanine, glutamine and leucine on a low carb diet and have seen some great improvements in strength, muscle and fat loss.

    There will more posts coming and maltodextrin/dextrose will be one of them.

    Living Strong
    Stephen

  • Raffy Peran Says:

    This article is very helpful. So i can take 2g of Beta Alanine after lunch, then 2g Beta Alanine+1.5g kre-alkalyn+1.5g glutamine 30mins before a workout then finally 2g Beta Alanine+1.5g kre-alkalyn+1.5g glutamine and a whey protein shake after i workout right? Nothing is wasted nor harmful with this combination?

    Ill continue to follow your blog. More power!

    Raffy P.
    Manila

  • Raffy Peran Says:

    And I’m wondering what should i take during my non-workout days. I hope you could guide me. Many thanks again.

  • Stephen Morris Says:

    Sounds like a good combo, although i cant vouch for kre alkalyn.

  • Stephen Morris Says:

    still take 4-6g on your day off.

  • Theo Vlamis Says:

    Cool blog, really enjoy the info. Just wanted to ask a question in regards to my training and using beta alanine. I train and compete in brazilian jiu jitsu also do some freestyle wrestling and a strength & conditioning session once a week. As these sports are high endurance do you recommend beta alanine for endurance support.

  • Stephen Morris Says:

    Hi Theo.
    Yes I would recommend Beta Alanine for these sports, as they are high endurance and you would benefit immensely.

    Living Strong
    Stephen

  • Theo Vlamis Says:

    Hi Stephen.
    thanks for your feedback. Was also wondering if I need to cycle the Beta Alanine as u do for example creatine and if so how long for?

  • Stephen Morris Says:

    Hi Theo
    As the blog post says “studies of up to 12 weeks have shown no negative changes across a wide range of blood, biochemical, haematological and hormonal markers making it safe to consume for up to 3 months.” So I would cycle it but anything after 3 months is your decision purely as studies havent got past the 3 month mark. However I am aware that there are athletes taking it for over 6 months without cycling.

    Hope that helps.

    Living Strong
    Stephen

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